Rouleaux formation can, however, be a normal physiological finding in horses, cats, and pigs.
2.
On peripheral blood smear, the rouleaux formation of red blood cells is commonly seen, though this is not specific.
3.
Rouleaux formation can also occur in association with some lymphoproliferative disorders in which one or more immunoglobulins are secreted in high amounts.
4.
Conditions which cause rouleaux formation include infections, multiple myeloma, Waldenstrom's macroglobulinemia, inflammatory and connective tissue disorders, and cancers.
5.
Those with myeloma will typically display a rouleaux formation on a peripheral smear and a large globulin gap, indicative of a significant paraprotein load.
6.
This is known as " rouleaux formation ", and it occurs more often if the levels of certain serum proteins are elevated, as for instance during inflammation.
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